Comprehensive Multi-Omics Analysis of Early-Stage Lung Cancer Exhibiting Distinct Phenotypes
The goal of this observational study is to investigate the multi-omics characterization early-stage lung cancer exhibiting distinct phenotypes including lung cancer associated with cystic airspaces, multiple primary lung cancers, and so on. The main questions it aims to answer are: * What are the differences in pathogenesis of non-small cell lung cancer with different phenotypes explored by multi-omics? * Whether differential genes lead to potential prognostic models and therapeutic targets? Participants will be followed up after surgery to answer prognosis: whether they have recurred, and the time to recurrence.
• Male or female patients:18-75 years old;
• ECOG score:0-1;
• Histopathologically confirmed TNM stage I-II NSCLC;
• Considered multiple or solitary primary lung cancer by clinical criteria (Martini-Melamed criteria and ACCP criteria);
• Good compliance, family members agree to cooperate to receive survival follow-up;
• Understand and voluntarily sign the informed consent.
• Male or female patients:18-75 years old;
• ECOG score:0-1;
• Histopathologically confirmed TNM stage I-II NSCLC;
• CT findings show solitary or multiple nodules with cystic airspaces.